Growth control and metabolism
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چکیده
منابع مشابه
Growth control and metabolism
mTOR is the target of the immunosuppressive drug rapamycin and the central component of a nutrientand hormone-sensitive signaling pathway that regulates cell growth and proliferation. We now appreciate that this pathway becomes deregulated in many human cancers and has an important role in the control of metabolism and aging. We have identified two distinct mTORcontaining proteins complexes, on...
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In humans, low levels of growth hormone (GH) and its mediator, IGF-1, associate with hepatic lipid accumulation. In mice, congenital liver-specific ablation of the GH receptor (GHR) results in reductions in circulating IGF-1 and hepatic steatosis, associated with systemic insulin resistance. Due to the intricate relationship between GH and IGF-1, the relative contribution of each hormone to the...
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It is an interesting fact (Macfarlane, 1984) that 58 years elapsed between the publication of the studies of Burdon Sanderson and of Lister showing the antibacterial action of members of the genus Penicillium (Burdon Sanderson, 187 1 ; Lister, 187 1) and Fleming's somewhat more celebrated paper (Fleming, 1929) to the same effect. Coincidentally enough, a similar period links this latter date wi...
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The control of growth is a poorly understood aspect of animal development. This thesis focuses on body size regulation in Caenorhabditis elegans, and in particular, how worms grow to a certain size. In C. elegans, a key regulator of size is the TGFβ homologue DBL-1. Mutations that deplete the worm of DBL-1 result in a small body size, whereas overexpression of the gene renders long animals. The...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2012
ISSN: 1753-6561
DOI: 10.1186/1753-6561-6-s3-o22